The inhibition of cerebral glutamine synthetase by structural analogs of the convulsant dl-methionine sulfoximine
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چکیده
منابع مشابه
The inhibition of cerebral glutamine synthetase by structural analogs of the convulsant dl-methionine sulfoximine.
GLUTAMINE synthetase [L-glutamate-ammonia ligase (ADP)] (EC 6.3.1.2) of rat cerebral cortex may be readily inhibited by the convulsant agent dl-methionine-di-sulfoximine (MSO), both in vitro and in vivo. 1, 8 Although in vitro this inhibition is readily reversible by excess substrate, L-glutamate, the inhibition in vivo appears to reflect a nonreversible interaction of the convulsant drug with ...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 1966
ISSN: 0006-2952
DOI: 10.1016/0006-2952(66)90312-1